768 Nerve fibers connect with keratinocytes via synapse-like structure and participate in the development of psoriasis

Psoriasis is a polygenic hereditary chronic inflammatory systemic disease mediated by T cells and dendritic cells. At present, the research on psoriasis mostly focuses immunological mechanism, few studies focus role of neural mediators in development disease. Studies have confirmed existence molecular "dialogue" between nerve fibers keratinocytes. Our previous study also found that protrusions extend to keratinocytes form "synapse-like" structures surface In psoriatic lesions, our results illustrated skin increased were distributed closely around several immune Also, genes related sensory disrupted improved after biologics treatment. order explore psoriasis, we conducted imiquimod induced psoriasis-like dermatitis spinal cord hemi-section model. We alleviated impairment, with inhibition abnormal keratinocyte proliferation. Botulinum toxin A pretreatment inhibiting secretion neuropeptide. summary, connected via synapse-like structure participated progression psoriasis. Impairment could improve mouse